Dinamo Minsk 2-0 Red Bull Salzburg 
(Rassadkin 57′ e Adamovic 90’+3)
FK Qäbälä 0-0 Panathinaikos 
Astra Giurgiu 3-2 AZ Alkmaar 
(Boldrin 25′, Alibec 41′ e Damdea 45’+3 / Henriksen 11′ e Janssen 13′)
Zorya 0-1 Legia Warszawa 
(Kucharczyk 48′)
Molde 2-0 Standard Liège 
(Hoiland 24′ e Elyounoussi 28′)
PAOK 5-0 Brondby 
(Mak 17′, 80′ e 82′, Pelkas 36′ e Garry Rodrigues 51′)
Ajax 1-0 FK Jablonec 
(Milik 54′ g.p.)
Slovan Liberec 1-0 Hajduk Split 
(Pokorny 79′)
Sparta Praha 3-1 FC Thun 
(Nhamoinesu 43′, Dockal 45’+1 e 90’+4 / Sutter 5′)
FK Krasnodar 5-1 HJK 
(Ojala 8′ p.b., Mamaev 9′ g.p., Smolov 57′ g.p.m Wanderson 61′ e Gazinskiy 63′ / Jallow 18′)
FC Milsami Orhei 1-1 Saint-Étienne 
(Bud 57′ / Hamouma 40′)
Steaua Bucuresti 0-3 Rosenborg
(Mikkelsen 61′, Helland 67′ e Jensen 90’+3)
Rabotnicki 1-1 Rubin Kazan
(Ristevski 85′ / Karadeniz 69′)
Young Boys 0-1 Karabakh
(Richard 67′)
Atromitos 0-1 Fenerbahçe 
(Robin Van Persie 90′)
MSK Zilina 3-2 Athletic 
(Paur 66′, Willian 77′ e 90’+4 / Sabin 16′ e Kike Sola 33′)
SCR Altach 0-1 Belenenses 
(Tiago Caeiro 13′)
Bordeaux 1-0 Kairat 
(Khazri 27′)
Odd 3-4 Borussia Dortmund 
(Samuelsen 2′, Nordkvelle 20′ e Ruud 22′ / Aubameyang 34′ e 76′, Kagawa 47′ e Mkhitaryan 85′)
Plzen 3-0 FK Vojvodina 
(Kopic 25′ e 82′ e Vanek 51′)
Southampton 1-1 Midtjylland
(Rodriguez 56′ g.p. / Sparv 45′)
Lech Poznan 3-0 Videoton 
(Linetty 11′, Thomalla 57′ e Tralka 68′)